To have natural scroll for ubuntu that applied to system wide, do the following command on terminal:     sudo nano /usr/share/X11/xorg.conf.d/20-natural-scrolling.conf Then in the editor copy (ctrl+c) and paste (ctrl+shift+v) below: Section “InputClass”      Identifier “natural scrolling for mouse wheel”     MatchIsPointer “on”     MatchDevicePath “/dev/input/event*”     Driver “mouse”     Option “Device” “/dev/input/mice”     Option “Protocol” “Auto”     Option “ZAxisMapping” “5 4” EndSection Save (ctrl + 0) and Exit (ctrl+x) Reboot (sudo reboot) After reboot, now you have natural scroll in your ubuntu system